Julien Orts

Molecular interactions are at the basis of all biological processes and often include specific interactions between macromolecules (protein, RNA, DNA) and small-molecule ligands The overarching goal of Julien Orts’ ERC project "CLAR" is to develop a calorimeter at atomic resolution that will shed new light on molecular interactions. It is anticipated that quantitative thermodynamic measurements within molecules and molecular complexes will open a new avenue in the fundamental understanding of how atomistic mechanisms create a function. Beyond the fundamental findings, applications in translational medicine, drug design, and computer-assisted molecular design could follow.